A Systematic Review of Natural Products for the Alzheimer's Disease
Mopuri Jyothsna
Department of Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) – Autonomous, KR Palli Cross, Chiyyedu (Post), Anantapur, Andhra Pradesh, 515721, India.
Akula Ruchitha Sai
Department of Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) – Autonomous, KR Palli Cross, Chiyyedu (Post), Anantapur, Andhra Pradesh, 515721, India.
Aaravula Hemanth Babu
Department of Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) – Autonomous, KR Palli Cross, Chiyyedu (Post), Anantapur, Andhra Pradesh, 515721, India.
Buddadasari Snehitha
Department of Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) – Autonomous, KR Palli Cross, Chiyyedu (Post), Anantapur, Andhra Pradesh, 515721, India.
K Baktha Bandhavi
Department of Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) – Autonomous, KR Palli Cross, Chiyyedu (Post), Anantapur, Andhra Pradesh, 515721, India.
K Somasekhar Reddy
Department of Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) – Autonomous, KR Palli Cross, Chiyyedu (Post), Anantapur, Andhra Pradesh, 515721, India.
Bhupalam Pradeep Kumar *
Department of Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) – Autonomous, KR Palli Cross, Chiyyedu (Post), Anantapur, Andhra Pradesh, 515721, India.
*Author to whom correspondence should be addressed.
Abstract
Alzheimer's disease (AD) is a progressive neurodegenerative disorder marked by the accumulation of tau tangles and amyloid plaques, which results in cognitive decline. Natural substances and phytomedicines with antioxidant, anti-inflammatory, anti-amyloidogenic, and neuroprotective properties offer promising therapeutic modalities for AD. The investigation of these plant-based remedies is in line with the goal of developing safe, effective, multimodal, and culturally sensitive therapies that can be used to manage or cure a variety of illnesses while minimizing side effects and enhancing general health. The antioxidant effectiveness of these treatments is demonstrated by a number of patents, with the inhibition of tau hyperphosphorylation among the suggested mechanisms. In addition, a few natural extracts show promise in crossing the blood-brain barrier, and some have anti-inflammatory qualities as well.
Keywords: Alzheimer's disease, cognitive impairment, health disorders, phytomedicines