ANTICANCER ACTIVITY OF Pedalium murex Linn METHANOLIC LEAVES EXTRACT AGAINST A549 HUMAN LUNG CANCER CELL LINE
S. AZHAGU MADHAVAN *
PG & Research Department of Zoology & Biotechnology, A. Veeriya Vandayar Memorial Sri Pushpam College, (Autonomous) Poondi, Thanjavur – 613503, Tamil Nadu, India.
P. VINOTHA
PG & Research Department of Bio-Chemistry, Meenakshmi Chandrasekaran College of Arts and Science, Karambayam-614601, Pattukkottai, Thanjavur District, Tamil Nadu, India.
V. UMA
Sri Sai Apollo Educational Insttute, Bio-Chemistry, Veppur- 60634, Cuddalore District, Tamil Nadu, India.
M. MAHADEVI
PG & Research Department of Botany & Microbiology, A. Veeriya Vandayar Memorial Sri Pushpam College, (Autonomous) Poondi, Thanjavur – 613503, Tamil Nadu, India.
*Author to whom correspondence should be addressed.
Abstract
Pedalium murex (Pedaliaceae), commonly called Large Caltrops, is understood for its pharmacological uses in traditional medicine system. It is reported to possess excellent medicinal properties that helps cure reproductive disorders, mainly impotency in men, nocturnal emissions, gonorrhea also as leucorrhoea in women. Apart from that, it also contains remedy for urinary and gastrointestinal tract disorders. Pharmacologically, the plant has been explored for antiulcerogenic, nephroprotective, hypolipidemic, sexual enhancer, mitigating, antidermatophytic, cancer prevention agent, antimicrobial and insecticidal exercises. The present review may be a bundle of data collected from the published research articles and highlights the phytochemical and pharmacological aspects of P. murex. Highly presences of methnolic extract are information will be helpful in developing the new formulation with therapeutic and economical value in the future. A549 cells treated with Pedalium murex leaves methanolic extract in different hours (6, 12, 24 and 36 hours) after the 36 hours the cells growth are controlled.
Keywords: Phyllodistomum guptai, Human cancer cell line A549, parasite, inorganic elements, body cavity, phytomedicine, freshwater fishes, Pedalium murex