Metabolic and Immune Influences in Spodoptera littoralis (Boisduval) in Response to Treatment with Emamectin Benzoate and its Nanoform

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Published: 2023-07-31

Page: 347-365


Hassan S. H. Amin

Plant Protection Research Protection Institute, Agricultural Research Center, Dokki, Giza, P.O. Box: 12611, Egypt.

Mohamed S. Salama

Department of Entomology, Faculty of Science, Ain Shams University, Abassia, Cairo, P.O. Box: 11566, Egypt.

El-Gohary E. A. El-Gohary

Department of Entomology, Faculty of Science, Ain Shams University, Abassia, Cairo, P.O. Box: 11566, Egypt.

Tarek A. A. El-Sheikh

Plant Protection Research Protection Institute, Agricultural Research Center, Dokki, Giza, P.O. Box: 12611, Egypt.

Sara M. I. Abd El-Kareem *

Plant Protection Research Protection Institute, Agricultural Research Center, Dokki, Giza, P.O. Box: 12611, Egypt.

*Author to whom correspondence should be addressed.


Abstract

Insecticide resistance and negative effects on natural ecosystems result from the careless use of synthetic pesticides for controlling the cotton leafworm Spodoptera littoralis. Recent efforts to control this pest have used emamectin benzoate and other members of a new family of chemical insecticides with a confined mode of action and specific target ranges. Nanotechnology instruments are increasingly employed in agricultural operations because of their low-cost, minimal toxicity, and safe concentration. Through biochemical assessments of several enzymes associated with insecticide resistance and vitellogenin gene expression, the present research sought to comprehend the method of action of nano pesticides. The 4th instar larvae were treated with the LC50 of emamectin benzoate (EMB), silver nanoparticles (AgNPs), and the nanoform of emamectin benzoate (EMB+AgNPs) for 24 h. Larvae that survived treatment were collected to assay the influence of tested compounds on total body contents, detoxifying enzymes activity, and vitellogenin (Vg) gene expression. The findings showed that treatment with sublethal concentrations reduced the total body contents and adversely influenced the detoxifying enzymes. The results also demonstrated that Vg expression was down-regulated by EMB treatment while upregulated by AgNPs and EMB+AgNPs therapy. So, we can conclude that these substances have been shown to directly impact the body, including the enzymes responsible for detoxification. Nanopesticides represent a better substitute for synthetic insecticides for managing S. littoralis either directly through the killing effect or latent through the influence on detoxifying enzymes and gene expression.

Keywords: Polistes (Polistes,), Spodoptera littoralis, indicus Stolfa, nanopesticides, Uttar Pradesh, vitellogenin gene expression, India, detoxifying enzymes, metabolic response, immune response


How to Cite

Amin , Hassan S. H., Mohamed S. Salama, El-Gohary E. A. El-Gohary, Tarek A. A. El-Sheikh, and Sara M. I. Abd El-Kareem. 2023. “Metabolic and Immune Influences in Spodoptera Littoralis (Boisduval) in Response to Treatment With Emamectin Benzoate and Its Nanoform”. Asian Journal of Advances in Research 6 (1):347-65. https://jasianresearch.com/index.php/AJOAIR/article/view/279.

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References

Kandil MA, Fouad EA, El Hefny DE, Abdel-Mobdy YE. Toxicity of fipronil and emamectin benzoate and their mixtures against cotton leafworm, Spodoptera littoralis (Lepidoptera: Noctuidae) with relation to GABA content. Journal of Economic Entomology, Oxford University Press. 2020;113:385–9. Available:https://doi.org/10.1093/jee/toz232

Croft BA. Arthropod biological control agents and pesticides. Arthropod Biological Control Agents and Pesticides, John Wiley and Sons Inc., New York, USA. 1990;723. Available:https://doi.org/10.1201/b16042-5

Abd Elnabi A, Badawy M, Saad AF, Mohamed S. Efficacy of some pyrethroid nanopesticides against cotton leaf worm Spodoptera littoralis: Toxicity, biochemical and molecular docking studies. Egyptian Journal of Chemistry, National Information and Documentation Centre (NIDOC), Academy of Scientific Research and Technology, ASRT. 2021;0:1047–55.

Available:https://doi.org/10.21608/ejchem.2020.45275.2946

Barrania AA, Selim SA. Laboratory Evaluation of some insecticides against cotton leafworm, Spodoptera littoralis (Boisd) (Lepidoptera: Noctuidae). Egyptian Academic Journal of Biological Sciences, F Toxicology & Pest Control. 2020;8: 16–29.

Available:https://doi.org/10.21608/eajbsf.2020.114538

Venkateswari G, Krishnayya PV, Rao PA, Murthy KVMK. Bioefficacy of abamectin and emamectin benzoate against Spodoptera litura (Fab.). Pesticide Research Journal. 2008;20:229–33.

Cvetovich RJ, Kelly DH, DiMichele LM, Shuman RF, Grabowski EJJ. Syntheses of 4″-epi-Amino-4″-deoxyavermectins B1. Journal of Organic Chemistry, American Chemical Society. 1994;59:7704–8.

Available:https://doi.org/10.1021/JO00104A028/SUPPL_FILE/JO00104A028_SI_001.PDF

Yang D, Cui B, Wang C, Zhao X, Zeng Z, Wang Y, et al. Preparation and Characterization of Emamectin Benzoate Solid Nanodispersion. Journal of Nanomaterials, Hindawi Limited; 2017. Available:https://doi.org/10.1155/2017/6560780

Ishaaya I, Kontsedalov S, Horowitz AR. Emamectin, a novel insecticide for controlling field crop pests. Pest Management Science, John Wiley & Sons, Ltd. 2002;58:1091–5. Available:https://doi.org/10.1002/ps.535

Moussa S, Baiomy F, Sharma A, El-adl FE. The Status of Tomato Leafminer ; Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae) in Egypt and Potential effective pesticides insect molecular biology and biotechnology unit, Insect Resistance Group, International Centre for Genetic Engineering a. Academic Journal of Entomology. 2013;6:110–5.

Metayi MHA, Ibrahiem MAM, El-Deeb DA. Toxicity and Some Biological Effects of Emamectin Benzoate, Novaluron and Diflubenzuron against Cotton Leafworm. Alexandria Science Exchange Journal: An International Quarterly Journal of Science Agricultural Environments, Egypts Presidential Specialized Council for Education and Scientific Research. 2015;36:350–7.

Available:https://doi.org/10.21608/asejaiqjsae.2015.2944

Abdel-Baky NF, Alhewairini SS, Bakry MMS. Emamectin-benzoate against Tuta absoluta meyrick and Spodoptera littoralis boisduval larvae. Pakistan Journal of Agricultural Sciences. 2019;56:801–8.

Available:https://doi.org/10.21162/PAKJAS/19.8082

Abd El-Rahman SF, Ahmed SS, Abdel Kader MH. Toxicological, biological and biochemical effects of two nanocomposites on cotton leaf worm, Spodoptera littoralis (Boisduval, 1833). Polish Journal of Entomology. 2020;89:101–12.

Available:https://doi.org/10.5604/01.3001.0014.2319

Mokbel ES, Huesien A, Abdel-Hamid H, Osman H. Assessment of resistance risk to emamectin benzoate, indoxacarb and spinetoram in Cotton Leaf Worm, Spodoptera littoralis (Boisd.). Egyptian Academic Journal of Biological Sciences, F Toxicology & Pest Control, Egyptian Society of Biological Sciences. 2017;9:9–18.

Available:https://doi.org/10.21608/eajbsf.2017.17048

Mokbel EMS, Fouad EA, El-Sherif SANANNS. Mokbel ESM, Fouad EA, El-Sherif SANANN. Resistance monitoring of cotton leaf worm, Spodoptera Littoralis (Boisduval) (Lepidoptera: Noctuidae) Against Certain Alternative Insecticides of Four Different Field Populations in Egypt. J Biol Chem Environ Sci. 2019;14:319–33.

Mokbel ES, Huesien A. Sublethal effects of emamectin benzoate on life table parameters of the cotton leafworm, Spodoptera littoralis (Boisd.). Bulletin of the National Research Centre, Springer Open. 2020;44:1–8.

Available:https://doi.org/10.1186/s42269-020-00412-x

Singh G, Pai RS. Optimized self-nanoemulsifying drug delivery system of atazanavir with enhanced oral bioavailability: in vitro/in vivo characterization. Taylor & Francis. 2014;11:1023–32.

Available:https://doi.org/10.1517/17425247.2014.913566

Atta S, Bera M, Chattopadhyay T, Paul A, Ikbal M, Maiti MK, et al. Nano-pesticide formulation based on fluorescent organic photoresponsive nanoparticles: For controlled release of 2,4-D and real time monitoring of morphological changes induced by 2,4-D in plant systems. RSC Advances, The Royal Society of Chemistry. 2015;5:86990–6.

Available:https://doi.org/10.1039/C5RA17121K

Jindal AB, Bachhav SS, Devarajan PV. In situ hybrid nano drug delivery system (IHN-DDS) of antiretroviral drug for simultaneous targeting to multiple viral reservoirs: An in vivo proof of concept. International Journal of Pharmaceutics, Elsevier. 2017;521:196–203. Available:https://doi.org/10.1016/J.IJPHARM.2017.02.024

Chaudhry N, Dwivedi S, Chaudhry V, Singh A, Saquib Q, Azam A, et al. Bio-inspired nanomaterials in agriculture and food: Current status, foreseen applications and challenges. Microbial Pathogenesis, Academic Press. 2018;123:196–200.

Available:https://doi.org/10.1016/J.MICPATH.2018.07.013

Sharma S, Singh S, Ganguli AK, Shanmugam V. Anti-drift nano-stickers made of graphene oxide for targeted pesticide delivery and crop pest control. Carbon, Pergamon. 2017;115:781–90. Available:https://doi.org/10.1016/J.CARBON.2017.01.075

Jindal AB, Bachhav SS, Devarajan PV. In situ hybrid nano drug delivery system (IHN-DDS) of antiretroviral drug for simultaneous targeting to multiple viral reservoirs: An in vivo proof of concept. International Journal of Pharmaceutics, Elsevier. 2017;521:196–203. Available:https://doi.org/10.1016/J.IJPHARM.2017.02.024

Sun Y, Liang J, Tang L, Li H, Zhu Y, Jiang D, et al. Nano-pesticides: A great challenge for biodiversity? Nano Today, Elsevier. 2019;28:100757. Available:https://doi.org/10.1016/J.NANTOD.2019.06.003

Alhag SK, Al-Mekhlafi FA, Abutaha N, Abd Al Galil FM, Wadaan MA. Larvicidal potential of gold and silver nanoparticles synthesized using Acalypha fruticosa leaf extracts against Culex pipiens (Culicidae: Diptera). Journal of Asia-Pacific Entomology, Elsevier. 2021;24:184–9. Available:https://doi.org/10.1016/J.ASPEN.2020.12.007

Elabasy A, Shoaib A, Waqas M, Jiang M, Shi Z. Synthesis, Characterization, and Pesticidal Activity of Emamectin Benzoate Nanoformulations against Phenacoccus solenopsis Tinsley (Hemiptera: Pseudococcidae). Molecules, Multidisciplinary Digital Publishing Institute (MDPI). 2019;24. Available:https://doi.org/10.3390/molecules24152801

Ahmed KS, Mikhail WZA, Sobhy HM, Radwan EMM, Salaheldin TA. Impact of nanosilver-profenofos on cotton leafworm, Spodoptera littoralis (Boisd.) larvae. Bulletin of the National Research Centre, Springer Open. 2019;43:1–9.

Available:https://doi.org/10.21608/EJCHEM.2019.6871.1581

Wang J, Wang WX. Low bioavailability of silver nanoparticles presents trophic toxicity to marine medaka (Oryzias melastigma). Environmental Science and Technology, American Chemical Society. 2014;48:8152–61.

Available:https://doi.org/10.1021/es500655z

Ga’al H, Fouad H, Mao G, Tian J, Jianchu M. Larvicidal and pupicidal evaluation of silver nanoparticles synthesized using Aquilaria sinensis and Pogostemon cablin essential oils against dengue and zika viruses vector Aedes albopictus mosquito and its histopathological analysis. Artificial Cells, Nanomedicine and Biotechnology, Taylor & Francis. 2018;46:1171–9.

Available:https://doi.org/10.1080/21691401.2017.1365723

Ibrahim AMA, Ali AM. Silver and zinc oxide nanoparticles induce developmental and physiological changes in the larval and pupal stages of Spodoptera littoralis (Lepidoptera: Noctuidae). Journal of Asia-Pacific Entomology, Elsevier. 2018;21:1373–8. Available:https://doi.org/10.1016/J.ASPEN.2018.10.018

Amin HSH, Ali MSS, El-Sheikh TAAEH, El-Gohary EGESA. Hematological and histopathological impacts of nano-emamectin benzoate against the larvae of the cotton leafworm, Spodoptera littoralis (Boisduval) (Lepidoptera: Noctuidae) under laboratory conditions. Beni-Suef University Journal of Basic and Applied Sciences, Springer Science and Business Media Deutschland GmbH. 2022;11:1–11. Available:https://doi.org/10.1186/S43088-022-00315-Y/FIGURES/3

Bai RG, Sabouni R, Husseini G. Green nanotechnology-A road map to safer nanomaterials. Applications of Nanomaterials: Advances and Key Technologies, Woodhead Publishing. 2018;133–59.

Available:https://doi.org/10.1016/B978-0-08-101971-9.00006-5

Huo Y, Yu Y, Chen L, Li Q, Zhang M, Song Z., et al. Insect tissue-specific vitellogenin facilitates transmission of plant virus. PLOS Pathogens, Public Library of Science. 2018;14:e1006909. Available:https://doi.org/10.1371/JOURNAL.PPAT.1006909

Garcia J, Munro ES, Monte MM, Fourrier MCS, Whitelaw J, Smail DA, et al. Atlantic salmon (Salmo salar L.) serum vitellogenin neutralises infectivity of infectious pancreatic necrosis virus (IPNV). Fish & Shellfish Immunology, Academic Press. 2010;29:293–7. Available:https://doi.org/10.1016/J.FSI.2010.04.010

Corona M, Libbrecht R, Wurm Y, Riba-Grognuz O, Studer RA, Keller L. Vitellogenin Underwent Subfunctionalization to Acquire Caste and Behavioral Specific Expression in the Harvester Ant Pogonomyrmex barbatus. PLOS Genetics, Public Library of Science. 2013;9:e1003730. Available:https://doi.org/10.1371/JOURNAL.PGEN.1003730

El-Guindy MA, El-Sayed MM, Issa YH. Biological and toxicological studies on the cotton leafworm Spodoptera littoralis Boisd. reared on natural and artificial diets. Zeitschrift Für Pflanzenkrankheiten Und Pflanzenschutz / Journal of Plant Diseases and Protection. 1979;86:180–9.

Eldefrawi ME, Toppozada A, Mansour N, Zeid M. Toxicological studies on the egyptian cotton Leafworm, Prodenia litura. I. Susceptibility of Different Larval Instars of Prodenia to Insecticides1. Journal of Economic Entomology, Oxford University Press (OUP). 1964;57:591–3.Available:https://doi.org/10.1093/jee/57.4.591

Amin TR. Biochemical and physiological studies of some insect growth regulators on the cotton leafworm, Spodoptera littoralis (Boisd.) [Ph. D.]. Cairo University; 1998.

Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry, Academic Press. 1976;72:248–54.

Available:https://doi.org/10.1016/0003-2697(76)90527-3

DuBois Michel, Gilles KA, Hamilton JK, Rebers PA, Smith F. Colorimetric Method for Determination of Sugars and Related Substances. Analytical Chemistry. 1956; 28:350–6.

Knight JA, Anderson S, Rawle JM. Chemical basis of the sulfo-phospho-vanillin reaction for estimating total serum lipids. Clinical Chemistry, Oxford Academic. 1972;18:199–202. Available:https://doi.org/10.1093/clinchem/18.3.199

Habig WH, Pabst MJ, Jakoby WB. Glutathione S transferases. The first enzymatic step in mercapturic acid formation. Journal of Biological Chemistry, Elsevier. 1974;249:7130–9. Available:https://doi.org/10.1016/S0021-9258(19)42083-8

Barker SB, Summerson WH. The colorimetric determination of lactic acid in biological material. Journal of Biological Chemistry, Elsevier BV. 1941;138:535– 54. Available:https://doi.org/10.1016/s0021-9258(18)51379-x

Powell MEA, Smith MJH. The determination of serum acid and alkaline phosphatase activity with 4-aminoantipyrine (A.A.P.). Journal of Clinical Pathology. 1954;7:245–8. Available:https://doi.org/10.1136/jcp.7.3.245

Reitman S, Frankel S. A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. American Journal of Clinical Pathology, Am J Clin Pathol. 1957;28:56–63.

Available:https://doi.org/10.1093/ajcp/28.1.56

Ishaaya I. Observations on the phenoloxidase system in the armored scales Aonidiella aurantii and Chrysomphalus aonidum. Comparative Biochemistry and Physiology -- Part B: Biochemistry And, Pergamon. 1971;39: 935–43.

Available:https://doi.org/10.1016/0305-0491(71)90117-9

Shu Y, Zhou J, Tang W, Lu K, Zhou Q, Zhang G. Molecular characterization and expression pattern of Spodoptera litura (Lepidoptera: Noctuidae) vitellogenin, and its response to lead stress. Journal of Insect Physiology, Pergamon. 2009;55: 608–16. Available:https://doi.org/10.1016/j.jinsphys.2009.03.005

Snedecor GW, Cochran WG. Statistical methods. 7th ed. The Iowa State University Press, Ames, IA; 1980.

Piri F, Sahragard A, Ghadamyari M. Sublethal effects of spinosad on some biochemical and biological parameters of Glyphodes pyloalis Walker (Lepidoptera: Pyralidae). Plant Protection Science. 2014;50:135–44.

Available:https://doi.org/10.17221/50/2013-pps

Fagan WF, Siemann E, Mitter C, Denno RF, Huberty AF, Woods HA, et al. Nitrogen in insects: Implications for trophic complexity and species diversification. American Naturalist, The University of Chicago Press. 2002;160:784–802.

Available:https://doi.org/10.1086/343879

Nath BS, Suresh A, Varma BM, Kumar RPS. Changes in protein metabolism in hemolymph and fat body of the silkworm, Bombyx mori (Lepidoptera: Bombycidae) in response to organophosphorus insecticides toxicity. Ecotoxicology and Environmental Safety, Academic Press. 1997;36:169–73. Available:https://doi.org/10.1006/eesa.1996.1504

Genç H. General principles of insect nutritional ecology. Trakya University Journal of Social Science. 2006;7:53–7.

Abdel-Hafez H, Osman H. Effects of pyridalyl and emamectin benzoate on some biological and biochemical parameters of Spodoptera littoralis (Boisd.) and Albino rat. Egyptian Academic Journal of Biological Sciences A, Entomology, Egyptian Society of Biological Sciences. 2013;6:59–68. Available:https://doi.org/10.21608/eajbsa.2013.13238

Vojoudi S, Saber M, Gharekhani G, Esfandiari E. Toxicity and sublethal effects of hexaflumuron and indoxacarb on the biological and biochemical parameters of Helicoverpa armigera (Hübner) (Lepidoptera: Noctuidae) in Iran. Crop Protection, Elsevier. 2017;91:100–7. https://doi.org/10.1016/j.cropro.2016.09.020

Franeta F, Mirčić D, Todorović D, Milovac Ž, Granica N, Obradović S, et al. Effects of different insecticides on the antioxidative defense system of the European Corn Borer (Ostrinia nubilalis Hübner) (Lepidoptera: Crambidae) larvae. Archives of Biological Sciences. 2018;70:765–73. Available:https://doi.org/10.2298/ABS180701042F

Osman HH, Abdel-Hafez HF, Khidr AA. Comparison between the efficacy of two nanoparticles and effective microorganisms on some biological and biochemical aspects of Spodoptera littorals. International Journal of Agriculture Innovations and Research. 2015;3:1620–6.

Xu Z, Bai J, Li L, Liang L, Ma X, Ma L. Sublethal concentration of emamectin benzoate inhibits the growth of gypsy moth by inducing digestive dysfunction and nutrient metabolism disorder. Pest Management Science, John Wiley & Sons, Ltd. 2021;77:4073–83. Available:https://doi.org/10.1002/ps.6432

Hemingway J, Karunaratne SHPP. Mosquito carboxylesterases: A review of the molecular biology and biochemistry of a major insecticide resistance mechanism. Medical and Veterinary Entomology, John Wiley & Sons, Ltd. 1998;12:1–12.

Available:https://doi.org/10.1046/j.1365-2915.1998.00082.x

Serebrov V.V, Gerber ON, Malyarchuk AA, Martemyanov VV, Alekseev AA, Glupov VV. Effect of entomopathogenic fungi on detoxification enzyme activity in greater wax moth Galleria mellonella L. (Lepidoptera, Pyralidae) and role of detoxification enzymes in development of insect resistance to entomopathogenic fungi. Biology Bulletin. 2006;33:581–6.

Available:https://doi.org/10.1134/S1062359006060082

Chen XD, Seo M, Stelinski LL. Behavioral and hormetic effects of the butenolide insecticide, flupyradifurone, on Asian citrus psyllid, Diaphorina citri. Crop Protection, Elsevier Ltd. 2017;98:102–7.

Available:https://doi.org/10.1016/j.cropro.2017.03.017

Ahmed R, Freed S. Biochemical resistance mechanisms against chlorpyrifos, imidacloprid and lambda-cyhalothrin in Rhynchophorus ferrugineus (Olivier) (Coleoptera: Curculionidae). Crop Protection, Elsevier Ltd. 2021;143:105568.

Available:https://doi.org/10.1016/j.cropro.2021.105568

Zibaee A, Sendi JJ, Ghadamyari M, Alinia F, Etebari K. Diazinon resistance in different selected strains of chilo suppressalis (Lepidoptera: Crambidae) in Northern Iran. Journal of Economic Entomology. 2009;102:1189–96.

Available:https://doi.org/10.1603/029.102.0343

Bogwitz MR, Chung H, Magoc L, Rigby S, Wong,W. O’Keefe M, et al. Cyp12a4 confers lufenuron resistance in a natural population of Drosophila melanogaster. Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences. 2005;102:12807–12. Available:https://doi.org/10.1073/pnas.0503709102

Papadopoulos AI, Boukouvala E, Kakaliouras G, Kostaropoulos J, Papadopoulou-Mourkidou E. Effect of organophosphate and pyrethroid insecticides on the expression of GSTs from Tenebrio molitor pupae. Pesticide Biochemistry and Physiology, Academic Press Inc. 2000;68:26–33. Available:https://doi.org/10.1006/pest.2000.2489

Magdy M, Moawad F, Elsayed N, Nasr Sherif S. Biochemical and toxicological studies of some pesticides on cotton leafworm (Spodoptera littoralis). Arab Universities Journal of Agricultural Sciences, Ain Shams University, Faculty of Agriculture. 2020;0:0–0. Available:https://doi.org/10.21608/ajs.2020.20797.1137

Moriarty F. Persistent contaminants, compartmental models and concentration along food-chains. Ecological Bulletins (Stockholm), JSTOR. 1984;36:35– 45.

Wilce MCJ, Parker MW. Structure and function of glutathione S-transferases. Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular, Elsevier. 1994;1205:1–18.

Available:https://doi.org/10.1016/0167-4838(94)90086-8

Diamantino TC, Almeida E, Soares AMVM, Guilhermino L. Lactate dehydrogenase activity as an effect criterion in toxicity tests with Daphnia magna straus. Chemosphere, Pergamon. 2001;45:553–60.

Available:https://doi.org/10.1016/S0045-6535(01)00029-7

Wu RSS, Lam PKS. Glucose-6-phosphate dehydrogenase and lactate dehydrogenase in the green-lipped mussel (Perna viridis): Possible biomarkers for hypoxia in the marine environment. Water Research, Pergamon. 1997;31:2797–801.

Available:https://doi.org/10.1016/S0043-1354(97)00116-4

Bianconcini MSC, Medeiros LO, Medeiros LF, Mendes EG, Valente D. Glycolytic and hexosemonophosphate enzyme activities in the lantern muscles of the sea urchins, Arbacia lixula (Linn.), Echinometra lucunter (Linn.) and Lytechinus variegatus (Lamarck). Comparative Biochemistry and Physiology -- Part B: Biochemistry and, Pergamon. 1980;67:569–73.

Available:https://doi.org/10.1016/0305-0491(80)90416-2

Ribeiro S, Guilhermino L, Sousa JP, Soares AMVM. Novel bioassay based on acetylcholinesterase and lactate dehydrogenase activities to evaluate the toxicity of chemicals to soil isopods. Ecotoxicology and Environmental Safety, Academic Press. 1999;44:287–93. Available:https://doi.org/10.1006/eesa.1999.1837

Dixit G, Praveen A, Tripathi T, Yadav VK, Verma PC. Herbivore-responsive cotton phenolics and their impact on insect performance and biochemistry. Journal of Asia-Pacific Entomology, Elsevier. 2017;20:341–51.

Available:https://doi.org/10.1016/j.aspen.2017.02.002

Nath SB. Changes in carbohydrate metabolism in hemolymph and fat body of the silkworm, Bombyx mori L., exposed to organophosphorus insecticides. Pesticide Biochemistry and Physiology, Academic Press. 2000;68:127–37.

Available:https://doi.org/10.1006/pest.2000.2509

Hamadah Kh Sh, Basiouny AL, Ghoneim KS. Alterations in the lactate dehydrogenase activity of the desert locust Schistocerca gregaria by the wild plant Fagonia bruguieri (Zygophyllaceae). Egyptian Academic Journal of Biological Sciences A, Entomology. 2010;3:1–9. Available:https://doi.org/10.21608/eajbsa.2010.15182

Abou-Donia MB, Abdo KM, Timmons PR, Proctor JE. Brain acetylcholinesterase, acid phosphatase, and 2′,3′-cyclic nucleotide-3′-phosphohydrolase and plasma butyrylcholinesterase activities in hens treated with a single dermal neurotoxic dose of S,S,S-tri-n-butyl phosphorotrithioate. Toxicology and Applied Pharmacology, Academic Press. 1986;82:461–73.

Available:https://doi.org/10.1016/0041-008X(86)90281-4

Mordue W, Goldsworthy GJ. Transaminase levels and uric acid production in adult locusts. Insect Biochemistry, Pergamon. 1973;3:419–27. Available:https://doi.org/10.1016/0020-1790(73)90075-9

Gorman MJ, An C, Kanost MR. Characterization of tyrosine hydroxylase from Manduca sexta. Insect Biochemistry and Molecular Biology, Pergamon. 2007;37:1327–37. Available:https://doi.org/10.1016/j.ibmb.2007.08.006

Ashida M, Brey PT. Role of the integument in insect defense: Pro-phenol oxidase cascade in the cuticular matrix. Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences. 1995;92:10698–702. Available:https://doi.org/10.1073/pnas.92.23.10698

Ribeiro C, Simões N, Brehélin M. Insect immunity: The haemocytes of the armyworm Mythimna unipuncta (Lepidoptera: Noctuidae) and their role in defence reactions. In vivo and in vitro studies. Journal of Insect Physiology, Pergamon. 1996;42:815–22. Available:https://doi.org/10.1016/0022-1910(96)00048-0

Hillyer JF, Christensen BM. Mosquito phenoloxidase and defensin colocalize in melanization innate immune responses. Journal of Histochemistry and Cytochemistry, SAGE Publications Sage CA: Los Angeles, CA. 2005;53:689– 98.

Available:https://doi.org/10.1369/jhc.4A6564.2005

Cornet S, Gandon S, Rivero A. Patterns of phenoloxidase activity in insecticide resistant and susceptible mosquitoes differ between laboratory-selected and wild-caught individuals. Parasites and Vectors, Bio Med Central. 2013;6:1–11.

Available:https://doi.org/10.1186/1756-3305-6-315

Wang S, Miao S, Yang B, Wang Z, Liu Q, Wang R, et al. Initial characterization of the vitellogenin receptor from a Psocoptera insect: Function analysis and RNA interference in Liposcelis entomophila (Enderlein). Journal of Stored Products Research, Pergamon. 2021;92:101803. Available:https://doi.org/10.1016/J.JSPR.2021.101803

Kubo I, Kinst-Hori I, Nihei KI, Soria F, Takasaki M, Calderón JS, et al. Tyrosinase Inhibitors from Galls of Rhus javanica Leaves and their effects on insects. Zeitschrift Fur Naturforschung - Section C Journal of Biosciences, Verlag der Zeitschrift fur Naturforschung. 2003;58: 719–25. Available:https://doi.org/10.1515/znc-2003-9-1022

Nunes FMF, Ihle KE, Mutti NS, Simões ZLP, Amdam GV. The gene vitellogenin affects microRNA regulation in honey bee (Apis mellifera) fat body and brain. Journal of Experimental Biology, The Company of Biologists. 2013;216:3724–32.

Available:https://doi.org/10.1242/jeb.089243

Huang L, Lu M, Han G, Du Y, Wang J. Sublethal effects of chlorantraniliprole on development, reproduction and vitellogenin gene (CsVg) expression in the rice stem borer, Chilo suppressalis. Pest Management Science, John Wiley & Sons, Ltd. 2016;72:2280–6. Available:https://doi.org/10.1002/PS.4271

Płachetka-Bożek A, Chwiałkowska K, Augustyniak M. Molecular changes in vitellogenin gene of Spodoptera exigua after long-time exposure to cadmium – Toxic side effect or microevolution? Ecotoxicology and Environmental Safety, Academic Press. 2018;147:461–70. Available:https://doi.org/10.1016/J.ECOENV.2017.08.067

Ullah F, Gul H, Desneux N, Qu Y, Xiao X, Khattak AM, et al. Acetamiprid-induced hormetic effects and vitellogenin gene (Vg) expression in the melon aphid, Aphis gossypii. Entomologia Generalis, E. Schweizerbart’sche Verlagsbuchhandlung. 2019;39:259–70. Available:https://doi.org/10.1127/ENTOMOLOGIA/2019/0887

Ullah F, Gul H, Tariq K, Desneux N, Gao X, Song D. Thiamethoxam induces transgenerational hormesis effects and alteration of genes expression in Aphis gossypii. Pesticide Biochemistry and Physiology, Academic Press. 2020;165: 104557.

Available:https://doi.org/10.1016/J.PESTBP.2020.104557

Zhou C, Yang X, Bin Yang H, Long GY, Jin DC. Effects of Sublethal Concentrations of Insecticides on the Fecundity of Sogatella furcifera (Hemiptera: Delphacidae) via the Regulation of Vitellogenin and Its Receptor. Journal of Insect Science, Oxford Academic. 2020;20:1–9. Available:https://doi.org/10.1093/JISESA/IEAA099

Gomaa SAS, Barakat EMS, Salama MS, El-Gohary EE. Effect of the Bacterium Paenibacillus larvae larvae on Vitellogenin Gene Expression of the Queen Honey Bee Apis mellifera L. Https://DoiOrg/104001/0030290096, Entomological Society of Southern Africa. 2021;29:96–103. Available:https://doi.org/10.4001/003.029.0096

Hafeez M, Li X, Yousaf HK, Khan MM, Imran M, Zhang Z, et al. Sublethal effects of bistrifluron on key biological traits, macronutrients contents and vitellogenin (SeVg) expression in Spodoptera exigua (Hübner). Pesticide Biochemistry and Physiology, Academic Press. 2021;174: 104802. Available:https://doi.org/10.1016/J.PESTBP.2021.104802

Han S, Wang D, Song P, Zhang S, He Y. Molecular characterization of vitellogenin and its receptor in Spodoptera frugiperda (J. E. Smith, 1797), and their function in reproduction of female. International Journal of Molecular Sciences, Multidisciplinary Digital Publishing Institute. 2022;23:11972. Available:https://doi.org/10.3390/IJMS231911972

Hua D, Li X, Yuan J, Tao M, Zhang K, Zheng X, et al. Fitness cost of spinosad resistance related to vitellogenin in Frankliniella occidentalis (Pergande). Pest Management Science, John Wiley & Sons, Ltd; 2022.

Available:https://doi.org/10.1002/PS.7253